Advise sufferers not to regulate the dose of acetaminophen and codeine phosphate tablets without the need of consulting a medical professional or other healthcare Expert.
Usually do not flush medicines down the toilet or pour them into a drain Except instructed to take action. Effectively discard this item when it truly is expired or no more essential. Speak to your pharmacist or area squander disposal enterprise.
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Mix acetaminophen and codeine phosphate tablets (don't crush) using an unpalatable compound such as Grime, cat litter, or used espresso grounds;
Discuss with your healthcare provider about naloxone, a medication to the unexpected emergency treatment method of an opioid overdose.
Neonatal Opioid Withdrawal Syndrome (NOWS) If opioid use is necessary for an extended length of time in the Expecting lady, advise the affected person of the risk of NOWS, which can be lifestyle-threatening if not recognized and handled. Make certain that management by neonatology industry experts are going to be available (see WARNINGS).
Keep an eye on for respiratory melancholy, Specially all through initiation and next any boost in dose; close monitoring might be important in sufferers at improved hazard and/or Those people acquiring concomitant remedies that improve the threat of respiratory depression
Dependence Equally tolerance and Actual physical dependence can develop in the course of Continual opioid therapy. Tolerance is actually a physiological condition click here characterized by a lessened reaction to a drug after recurring administration (i.
Codeine generates respiratory despair by direct motion on Mind stem respiratory facilities. The respiratory depression includes a discount inside the responsiveness in the brain stem respiratory centers to both of those increases in carbon dioxide stress and electrical stimulation.
If concomitant usage of CYP3A4 inhibitor check here is necessary, contemplate dosage reduction of acetaminophen and website codeine tablets until finally secure drug outcomes are click here attained. Appraise people at Regular intervals for respiratory melancholy and sedation.
Immediately after stopping use of here a CYP2D6 inhibitor, look at decreasing the acetaminophen and codeine phosphate tablets dosage and Consider the affected individual at Regular intervals for symptoms and symptoms of respiratory depression or sedation (see Safety measures, Drug Interactions).
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Will not give acetaminophen and codeine phosphate tablets to a baby young than 18 years of age soon after surgical treatment to eliminate the tonsils and/or adenoids.
Get health-related assistance right away When you have any incredibly major side effects, such as: fainting, seizure.